You will find a full list of supporters and interviews at the end of this clip.
The following video was projected behind the dNaga dancers during their performance of Proteinology during the 2016 World Parkinson’s Congress. The three movies following the quotes were created by researchers studying alpha- synuclein and producing cutting edge findings in their field. The following citations for the movies are listed in the order shown.
Movie S1. 3D surface rendering of confocal Z-stacks of the SNCA−/− neuron. The 3D rendering establishes the intracellular nature of hα-Syn inclusions and reveals their close association with nuclear and cytoplasmic membranes. hα-Syn staining is shown in green, β3 tubulin staining (performed to reveal neurons) is shown in red, and nuclear staining (DAPI) is shown in blue. The surface rendering of hα-Syn staining and DAPI was performed using Imaris software.
We thank the Lashuel and Fares lab at the Brain Mind Institute at the Swiss Federal Institute of Technology Lausanne for sharing this movie with us from their 2016 PNAS publication:
Fares M-B, Maco B, Oueslati A, et al. Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson’s disease. Proceedings of the National Academy of Sciences of the United States of America. 2016; 113(7): E912-E921. doi:10.1073/pnas.1512876113.
Alpha synuclein movie. Derived from NMR structures of synuclein bound to vesicles.
We thank Dr. Brock Schuman at the Keenan Research Center for Biomedical Science of St. Michael’s Hospital in Toronto ON, Canada for sharing this movie with us.
Atomic-Resolution Structure of Alpha-Synuclein Fibrils.
We thank Dr. Chad Rienstra and Marcus Tuttle at the University of Illinois at Urbana-Champaign for sharing this movie with us from their 2016 Nature publication:
Tuttle MD, Comellas G, Nieuwkoop AJ, et al. Solid-state nmr structure of a pathogenic fibril of full-length human alpha-synuclein. Nat.Struct.Mol.Biol. 2016; 23(5): 409-15. doi: 10.1038/nsmb.3194.